Running bngl model with mcell. Warning: total probability >1

Hello,

I am running a bngl model with mcell and I get the following warnings when I run it through VSCode:

Warning: total probability of reaction is > 1 (2215.57)

rxn class for reactants:

CaM(ca~0,camkii)@cp (4) + Ca@CP (3)

pathways were not initialized

0: products based on rule CaM(ca~0,camkii) + Ca -> CaM(ca~1,camkii) 1e+06 (id: 0)

CaM(ca~1,camkii)@cp (8)

cum_probs: 2215.57, max_fixed_p: 2215.57

Warning: total probability of reaction is > 1 (2215.57)

rxn class for reactants:

CaM(ca~1,camkii)@cp (8) + Ca@CP (3)

pathways were not initialized

0: products based on rule CaM(ca~1,camkii) + Ca -> CaM(ca~2,camkii) 1e+06 (id: 2)

CaM(ca~2,camkii)@cp (10)

cum_probs: 2215.57, max_fixed_p: 2215.57

Warning: total probability of reaction is > 1 (2215.57)

rxn class for reactants:

CaM(ca~2,camkii)@cp (10) + Ca@CP (3)

pathways were not initialized

0: products based on rule CaM(ca~2,camkii) + Ca -> CaM(ca~3,camkii) 1e+06 (id: 4)

CaM(ca~3,camkii)@cp (11)

cum_probs: 2215.57, max_fixed_p: 2215.57

 - I have tried reducing number of molecule counts released into the model, as well as reducing the reaction constants in the bngl file but that did not work. The only thing that worked was to reduce my model.config.time_step = 1e-20 but it's not ideal as I don'tget the warning but it increases simulation time by a fair amount (and will only get worse as I add more molecules). Does anyone have any insights as to how to resolve these warnings?

- It would be really helpful if I could get clarification on what the numbers in parenthesis mean, for example CaM(ca~0,camkii)@cp (4) + Ca@CP (3) - what do (4) and (3) represent?


Thank you in advance,
Susana.